Fig. 3: SNAC with BRAF p.V600E mutations. | Modern Pathology

Fig. 3: SNAC with BRAF p.V600E mutations.

From: Low-grade non-intestinal-type sinonasal adenocarcinoma: a histologically distinctive but molecularly heterogeneous entity

Fig. 3

Two tumors with concomitant BRAF p.V600E and AKT1 p.E17K mutations demonstrated biphasic populations of peripheral cuboidal cells with clear to pale eosinophilic cytoplasm (A; case 8) and central ductal cells that showed variable tubular (B; case 7), micropapillary (C; case 8), and papillary (D; case 7) architecture. The peripheral cells showed a true myoepithelial phenotype with positivity for both p40 (E; case 7) and calponin (F; case 7). Despite largely low-grade histology, both of these cases also showed high grade areas including overt sarcomatoid transformation in one case (G; case 8).

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