Fig. 1: Distinctive histo-morphological features of osteoblastoma-like osteosarcoma. | Modern Pathology

Fig. 1: Distinctive histo-morphological features of osteoblastoma-like osteosarcoma.

From: Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics?

Fig. 1

Histology of OB-like osteosarcoma show areas strongly resembling osteoblastoma (A–C) but merging with components with more obvious conventional osteosarcoma differentiation (A, arrowheads point to the OB-like differentiation) and destruction of pre-existing bone (B, arrowheads). Osteoblastomas present markedly similar morphology and usually show strong and consistent nuclear FOS expression (D). High-grade atypia of an osteoblastic (E) and chondroblastic (F) osteosarcoma are shown for comparison.

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