Fig. 2: Distinct somatic mutation profiles of preinvasive and invasive LUAD. | Modern Pathology

Fig. 2: Distinct somatic mutation profiles of preinvasive and invasive LUAD.

From: Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma

Fig. 2

A Oncoprint summarizing the mutational landscape of adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). The histological subtypes (AIS/MIA/IAC), gender (Male/Female), smoking status (Smoker/Non-smoker), radiological phenotypes (ground-glass opacity (GGO) type; Mixed/Pure/Solid), and visceral pleural invasion status of each patient are indicated by various colors at the bottom of the oncoprint. Each column represents a patient and each row represents a gene. Values on the right represent the percentage of patients with mutations of a specific gene indicated on the left. Different colors denote the mutation types. Violin plots showing the significantly different mutation counts (B) and copy number variation (CNV) varscore (C) in AIS, MIA, and IAC. Heat map demonstrating the differential mutation detection rates in various genes (D) and oncogenic driver genes (E) across AIS, MIA, and IAC. F Dot plot illustrating the gene mutations that are significantly different between AIS and IAC. Red dots indicate a significantly higher detection rate (P value ≤0.05). False discovery rate corrected P-values were listed in Table S3.

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