Fig. 3: Distinct distribution of MAP2K1 and BRAF mutations in AIS and IAC. | Modern Pathology

Fig. 3: Distinct distribution of MAP2K1 and BRAF mutations in AIS and IAC.

From: Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma

Fig. 3

AIS tumors harbored more MAP2K1 insertion-deletion (indel) mutations and BRAF non-V600E mutations. Lollipop plots summarizing the mutation sites and mutation types in MAP2K1 (A) and BRAF (C) detected from the AIS (top) and IAC (bottom). Colors represent the mutation types. Each dot denotes a mutation in the specific site. The height of the lollipop indicates mutation counts. MAP2K1-mutant and BRAF non-V600E-mutant IAC had distinct concurrent mutations compared to their AIS counterpart. Bar plots at the top illustrate the distribution of detection rate for each mutation subtypes for MAP2K1 (i.e. Indels and missense mutations) (B) and BRAF (i.e. V600E, non-V600E kinase, and non-kinase mutations) (D) across AIS, MIA, and IAC. Heat maps at the middle and bottom summarize the detection rate of mutations in oncogenic drivers and tumor suppressor genes (TSGs) of the patients with AIS, MIA, and IAC who harbored certain mutation subtypes of MAP2K1 (B) and BRAF (D). BRAF V600E and non-kinase mutations were not detected in AIS.

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