Fig. 3: Detection of Gleason patterns 4 and 5 by DeepDx.

A Detection of Gleason grade groups (GG) 2–5 among all cases (top), GGs 2–5 among cancers (middle), Gleason pattern 5 among all cases (bottom). B The concordance of the % Gleason pattern 4 between DeepDx and the expert reviewer (kappa = 0.770, quadratic-weighted kappa = 0.940). C Evaluation of the correlation of Gleason pattern annotation in a representative case. D In ten examined cases, the gland-level patterns of DeepDx was significantly correlated to those of the expert reviewer (Pearson’s correlation P < 0.0001).