Fig. 2: HPV-independent, p53-wild-type verruciform acanthotic Vulvar Intraepithelial Neoplasia. | Modern Pathology

Fig. 2: HPV-independent, p53-wild-type verruciform acanthotic Vulvar Intraepithelial Neoplasia.

From: HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

Fig. 2

Three examples displaying verruciform architecture are shown. At low power, the lesions are markedly acanthotic and have a prominent keratin layer (A–C); projections can be variably shaped (A), long and horn-like (B) or bulbous (C). Higher magnification of each of these three lesions shows abnormal maturation with hypogranulosis, cytoplasmic pallor of mid and upper epithelial layers and parakeratosis (D–F). Notice the absence of cytologic atypia (nuclear enlargement, pleomorphism and loss of polarity) both in the base and in upper epithelial layers.

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