Fig. 4: Differential diagnosis of HPV-independent, p53-wild-type verruciform acanthotic Vulvar Intraepithelial Neoplasia. | Modern Pathology

Fig. 4: Differential diagnosis of HPV-independent, p53-wild-type verruciform acanthotic Vulvar Intraepithelial Neoplasia.

From: HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

Fig. 4

HPVi(p53mutant) differentiated VIN can present with prominent exophytic growth (A) and verruciform acanthosis (B, C). Attention to the basal cell layers is imperative in this differential, as HPVi(p53mutant) dVIN is characterized by loss of basal organization, nuclear enlargement, and prominent nucleoli (D, E).

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