Table 1 Proposed classification of flat intraurothelial lesions of the bladder.
Koss15 (1975) | Nagy et al.16 (1982) | Mostofi and Sesterhenn17 (1984) | 1986 CIS Workshop18 | Murphy et al. 20 (1994) | 1998 ISUP/WHO5 | 2004 WHO22 | 2016 WHO1 | 2021 GUPS[a25 |
|---|---|---|---|---|---|---|---|---|
• Simple hyperplasia • Atypical hyperplasia • CIS | • Atypia, NOS • Mild dysplasia • Moderate dysplasia • Severe dysplasia • CIS | • CIS, grade I • CIS, grade II • CIS, grade III | • Slight dysplasia (Intraurothelial neoplasia 1) • Moderate dysplasia (Intraurothelial neoplasia 2) • Marked dysplasia/CIS (Intraurothelial neoplasia 3) | • Dysplasia • CIS | • Hyperplasia • Reactive atypia • AUS • Dysplasia (Low-grade intraurothelial neoplasia) • CIS (High-grade intraurothelial neoplasia) | • Hyperplasiab (includes papillary and flat) • Reactive atypiab • AUSb • Dysplasiab (Low-grade intraurothelial neoplasia) • CIS (High-grade intraurothelial neoplasia) | • UPUMP (includes papillary and flat) • Reactive atypiab • AUSb • Dysplasia • CIS | • AUP-flat • Dysplasia • CIS |
