Fig. 2: Histological and immunohistochemical features of an IgG4-negative tissue specimen.
From: IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis
a An IgG4-negative sample meeting stage 4 of Seifert and Donath´s classical criteria for chronic sclerosing sialadenitis. Acinar atrophy and strong fibrosis can be seen in the sample. H&E, ×10. b Immunostaining for IgG4 of the same specimen, showing few scattered IgG4-positive plasma cells. ×40.
