Table 1 Summary of histopathological and immunohistochemical findings in the three groups: (A) nonspecific sialadenitis without known sialolithiasis, (B) sialolithiasis with sialadenitis, and (C) sialolithiasis without sialadenitis.
From: IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis
Group A (n = 59) | Group B (n = 56) | Group C (n = 50) | ||||
|---|---|---|---|---|---|---|
n | (%) | n | (%) | n | (%) | |
H&E staining | ||||||
Lymphoplasmacytic infiltrates | ||||||
Strong | 12 | (20) | 10 | (18) | 0 | (0) |
Moderate | 19 | (32) | 38 | (68) | 1 | (2) |
Mild/none | 28 | (48) | 8 | (14) | 49 | (98) |
Germinal centers | ||||||
Yes | 23 | (39) | 29 | (52) | 5 | (10) |
No | 36 | (61) | 27 | (48) | 45 | (90) |
Plasma cell infiltration | ||||||
Strong | 19 | (32) | 20 | (36) | 1 | (2) |
Moderate | 17 | (29) | 33 | (59) | 14 | (28) |
Mild/none | 23 | (39) | 3 | (5) | 35 | (70) |
Inflammatory infiltrate | ||||||
Affects whole gland | 21 | (36) | 28 | (50) | 5 | (10) |
Localized | 38 | (64) | 28 | (50) | 45 | (90) |
Fibrosis | ||||||
Strong | 10 | (17) | 10 | (18) | 0 | (0) |
Moderate | 23 | (39) | 42 | (75) | 22 | (44) |
Mild/none | 26 | (44) | 4 | (7) | 28 | (56) |
Storiform fibrosis | 9 | (15) | 16 | (29) | 0 | (0) |
Eosinophilia | ||||||
Yes | 7 | (12) | 16 | (29) | 7 | (14) |
No | 52 | (88) | 40 | (71) | 43 | (86) |
Acinar atrophy | ||||||
Yes | 21 | (36) | 25 | (45) | 1 | (2) |
No | 38 | (64) | 30 | (55) | 49 | (98) |
IgG4 staining | ||||||
≥70 IgG4+ plasma cells/HPF | 6 | (10) | 11 | (20) | 2 | (4) |
Additional IgGa and CD31b staining | ||||||
IgG4/IgG plasma cell ratio ≥ 40% | 1 | (17) | 2 | (18) | 1 | (50) |
Obliterative phlebitis | 3 | (50) | 2 | (18) | 0 | (0) |
