Table 1 Inclusion and exclusion criteria for case selection.

Inclusion criteria

○ Large B-cell lymphoma with lymphomatous effusion and no antecedent or concurrent solid tumor mass formation

○ Effusion sites: Pleural, peritoneal, and pericardial

○ Lymphoma types

   ■ Diffuse large B-cell lymphoma (DLBCL)

   ■ High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Exclusion criteria

○ Prior or concurrent solid diffuse large B-cell lymphoma (DLBCL) of nodal or extranodal sites, including serosal surfaces of body cavities

○ High suspicion of solid DLBCL from clinical examinations or imaging studies

○ Lymphoma types

   ■ HHV8 + primary effusion lymphoma (PEL), including solid variant

   ■ Plasmablastic lymphoma (PBL)

   ■ Burkitt lymphoma

   ■ Post-transplant lymphoproliferative disorder, monomorphic DLBCL or PBL type

   ■ Plasmablastic plasma cell myeloma presenting with body cavity effusions

   ■ Blastic or pleomorphic mantle cell lymphoma

   ■ Peripheral T-cell lymphoma or anaplastic large-cell lymphoma

○ Cases with prior or concurrent low-grade B-cell lymphoma

○ Cases lacking HHV8 studies