Fig. 1: A representative example of an index tumor in a salvage radical prostatectomy specimen exhibiting radiorecurrent prostate adenocarcinoma enriched in “cribriform” morphologies.

A low power view of the index tumor exhibits proliferation of variably sized dense cribriform glands (A). Intraductal carcinoma of the prostate characterized by large expansile and branching glands with dense cribriform architecture and intraluminal comedonecrosis (B). Cribriform Gleason pattern 4 adenocarcinoma characterized by back-to-back confluent and infiltrative dense cribriform glands (C). The tumor lacks morphological evidence of radiation treatment effect but background benign prostate tissue exhibits morphological evidence of radiation therapy (D).