Table 2 Summary of findings of included studies (all case series) analyzing MAML2 rearrangement in adenosquamous carcinoma and mucoepidermoid carcinoma in the same study.

Author, year	Location	Body site, sample size	Population (gender; age in years)	Relevant molecular determinations				Methodological quality^c
				ASC	ASC	MEC	MEC
				CRTC1-MAML2 fusion by RT-PCR (+/total)	MAML2 RA by FISH (+/total)	CRTC1-MAML2 fusion by RT-PCR (+/total)	MAML2 RA by FISH (+/total)
Saeki et al.³¹	Japan	Pancreas, n = 37 ASC^a	M:20F:17 Age: 12 patients <65; 25 patients ≥ 65	0/37	0/12	NA	NA	High
		Salivary gland, n = 20 MEC	M:8F:12 Age: 18 patients < 65; 2 patients ≥ 65	NA	NA	11/20	ND	High
Achcar et al.²⁸	USA	Lung, n = 98 (16 ASC, 17 MEC)	MEC patients M:5F:12 Age: 23–82 (mean 45) No data ASC	0/16	0/16	6/14	13/17	Moderate
Zhu et al.²²	China	Lung, n = 82 (40 ASC, 42 MEC)	MEC patients M:25F:17 Age: 14–76 (median 53.5) No data ASC	ND	0/40	ND	21/42	Moderate
Lennerz et al.²⁹	USA	Uterine cervix, n = 21 (14 ASC, 7 MEC)	MEC patients F: 7 Age: 28–88 (median 59) No data ASC	0/14	0/14	1/7	5/7^b	Moderate
Roden et al.³⁰	USA	Thymus, n = 5 (3 ASC, 2 MEC)	MEC patients M: 1F: 1 Age: 38, 68 No data ASC	ND	0/3	ND	2/2	Moderate

ASC adenosquamous carcinoma, MEC mucoepidermoid carcinoma, CRTC1 CREB regulated transcription coactivator 1 gene, MAML2 mastermind-like transcriptional coactivator 2, (+/total) positive cases of total reported cases, M male, F female, FISH Fluorescence in Situ Hybridization, NA not applicable, ND not done, No data ASC No demographics/population data for ASC cases reported, RA Rearrangement, RT-PCR reverse-transcription-polymerase chain reaction.
^aIncluding 16 pancreatic ASC with MEC-like features.
^bIncluding 3 cases showing CRTC1 RA, but not MAML2 RA.
^cMethodological quality of included case series assessed using an adapted version of the JBI Critical Appraisal Tool for case series (^34,35).

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