Fig. 1: Varied morphologic appearance of hyaline cartilage in teratoma component. | Modern Pathology

Fig. 1: Varied morphologic appearance of hyaline cartilage in teratoma component.

From: Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma

Fig. 1

The neoplastic cartilage in the teratoma component often formed well-circumscribed, discrete nodules of hyaline cartilage (1A, case 13, ×20) with a peripheral increase in cellularity. Most cases had a predominance of small, dark staining nuclei with features compatible with grade 1 (1B, case 20, ×40). A few cases had a moderate increase in nuclear size with intranuclear detail and several pinpoint nucleoli visible at high power (1C, case 7, ×40). Case 16 was notable for irregular, poorly defined nodules of cartilage that intermixed with adjacent cells (1D, case 16, ×20) and showed areas of myxoid change with poorly formed lacunae (1E, case 16, ×40). Occasional bizarre nuclei were present (1F, case 5, ×40); however, no cases showed features consistent with grade 3.

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