Fig. 3: Immunohistochemical findings with anti-IDH1/2 mutant antibody. | Modern Pathology

Fig. 3: Immunohistochemical findings with anti-IDH1/2 mutant antibody.

From: Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma

Fig. 3

The majority of cases without an IDH1/2 mutation (IDH wild-type) demonstrated a lack of staining with an IDH1/2 immunohistochemical stain (3A–3B, case 8, ×40), while a few cases showed focal aberrant staining. Two of the three cases with a molecularly confirmed IDH2 mutation demonstrated strong positive staining with an IDH1/2 immunohistochemical stain (3C–3D, case 17, ×40), while one was negative.

Back to article page