Fig. 5: Widespread loss of heterozygosity in myxoid pleomorphic liposarcoma (MPLPS). | Modern Pathology

Fig. 5: Widespread loss of heterozygosity in myxoid pleomorphic liposarcoma (MPLPS).

From: Myxoid pleomorphic liposarcoma is distinguished from other liposarcomas by widespread loss of heterozygosity and significantly worse overall survival: a genomic and clinicopathologic study

Fig. 5

Representative allelic log-odds-ratio (logOR) plots of MPLPS (A), pleomorphic liposarcoma (PLPS) (B), and myxoid/round cell liposarcoma (MRLPS) (C) generated by FACETS. Segment means are plotted in red lines. D Cohort level logOR represented by median logOR values on circos genomic plots with cytoband data across all samples in MPLPS (n = 7), PLPS (n = 9), MRLPS (n = 10), respectively. E Boxplots comparing the percentages of loss of heterozygosity (LOH) across the genome among MPLPS, PLPS and MRLPS. Center line corresponds to the median; lower and upper hinges correspond to 25th and 75th percentiles; upper and lower whiskers correspond to 1.5× inter-quartile range. Numbers between sample groups represent adjusted p-values by pairwise analysis (method = Benjamini-Hochberg, BH).

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