Fig. 6: FH deficient RCC with low grade oncocytic histology. | Modern Pathology

Fig. 6: FH deficient RCC with low grade oncocytic histology.

From: Low grade oncocytic tumors of the kidney: a clinically relevant approach for the workup and accurate diagnosis

Fig. 6

Fumarate hydratase-deficient low-grade oncocytic renal cell carcinoma (A) may closely resemble an SDH-deficient tumor. However, SDHB is retained in the tumor cells, whereas FH is completely lost. Diffuse nuclear and cytoplasmic positivity for 2SC in the tumor (B); this immunohistochemical stain is considered to be more sensitive than FH in these tumors.

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