Table 1 Categorization of low grade oncocytic tumors over decades.

From: Low grade oncocytic tumors of the kidney: a clinically relevant approach for the workup and accurate diagnosis

Low grade oncocytic tumors as outlined in WHO 2002 Classification of Renal tumors

● Renal Oncocytoma

● Chromophobe RCC

● Unclassified RCC

Low grade oncocytic tumors as outlined in WHO 2015 Classification of Renal tumors

● Renal Oncocytoma

● Chromophobe RCC

 - Hybrid oncocytic chromophobe tumor

● SDHB mutation-associated RCC

● Unclassified RCC

Low grade oncocytic tumors as outlined in Genitourinary Pathology Society update on renal neoplasia (2021)

● Renal Oncocytoma Chromophobe RCC

 - oncocytic renal neoplasm of low malignant potential, not further classified (sporadic cases)

 - hybrid oncocytic chromophobe tumor (tumors occurring in Birt Hogg Dube syndrome)

● SDHB mutation-associated RCC

● Eosinophilic, solid and cystic RCC

● Eosinophilic vacuolated tumor (EVT)

● Low grade oncocytic tumor (LOT)

● Fumarate hydratase-deficient RCC

 - Low grade tumors (“variant morphology”)

● Unclassified RCC

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