Table 2 Select timelines and publications in the historical evolution of our contemporary understanding and classification of low grade oncocytic tumors.

● Jaffe et al.⁷¹: in 1932 coined the term “onkocytoma” to describe the strikingly eosinophilic cells of Warthin’s tumor of the parotid gland

● Zippel⁷²: in 1941 described the first case of “renal oncocytoma” which was followed by sporadic cases over the next three decades

● Pierre Masson⁷³: in 1955 published the first likely illustration for “chromophobe RCC”

● Bannash et al.⁷⁴: described “chromophobe cells” in nitrosomorpholine-induced renal tumors in rats

● Klein and Valensi²: in 1976 “renal oncocytoma” gained acceptance as a distinct clinicopathologic entity after their publication of the first series of 13 cases

● 1981–1986: publication of studies of “metastatic oncocytoma” which led to the concept of grading of oncocytoma^{75,76,77,78,79,80}

● Theones et al.^81,82: in 1985, described the classic variant of chromophobe RCC, and 3 years later the same group described the eosinophilic variant

● Amin et al.⁸³: in 1997, “outline criteria of renal oncocytoma” in the light of understanding and acceptance of chromophobe RCC as a unique renal tumor

● Heidelberg classification of renal tumors (1997) and AJCC/WHO (1998) sponsored Rochester classification of renal tumors^84,85: basis of more “contemporary classification schema of RCC”

● Weirich et al.⁸⁶: coin the term “Hybrid Oncocytic tumor” morphology overlapping between renal oncocytoma and chromophobe RCC first described in five families with “familial renal oncocytoma”

● Tickoo et al.⁵¹: “Hybrid Oncocytic tumor” described in patients with “renal oncocytosis” (sporadic cases with multiple, often greater than 20 oncocytic lesions)

● Pavlovich et al.⁸⁷: first series outlining in detail morphologic descriptions of renal tumors in “Birt Hogg Dube syndrome”

● International Society of Urologic Pathologists (ISUP) organized Vancouver Classification (2013)⁸⁸: proposed the term “Hybrid Oncocytic Chromophobe tumors (HOCT)” for tumors with overlapping morphology, a term then also promulgated by WHO 2016⁴.

● Schreiner et al. and Guo et al.^36,89: publications on RCC associated with tuberous sclerosis complex (TSC) helped establish the uniqueness of a subset of tumors occurring in this setting as “Eosinophilic Solid Cystic RCC (ESC-RCC)” (2016) in a report of tumors occurring in sporadic setting identified by reviewing cases signed out as “unclassified, oncocytic or eosinophilic”⁹⁰

● Trpkov et al.³⁰: during some of the work related to ESC-RCC identify and analyze 28 cases of “Low Grade Oncocytic tumors (LOT)”, as a CK7 positive, CD117 negative distinct renal oncocytic tumor

● Gill et al. and Williamson et al.^91,92: highlight the striking uniqueness of tumors occurring in patients with succinate dehydrogenase (SDH) deficiency as “SDH-deficient RCC”

● Smith et al.³⁸: describe “low-grade oncocytic fumarate hydratase (FH) deficient RCC” which were uniquely different from the more common high-grade tubulopapillary tumors occurring in FH setting

● He et al.³⁴ and Chen et al.³³: two separate publications of a morphologically distinct subset of sporadic renal cell carcinoma with eosinophilic and vacuolated cytoplasm recommended to be called “Eosinophilic and Vacuolated tumor (EVT) of the kidney” by Genitourinary Pathology Society (GUPS)

● GUPS update on renal neoplasia (2021)^5,6: outlines two papers on updates in existing renal tumors, and on novel and emerging and provisional renal entities