Fig. 2: A colorectal adenocarcinoma with distinct MSH6 clonal loss by immunohistochemistry in a patient who was found to have a germline pathogenic variant in MSH6. | Modern Pathology

Fig. 2: A colorectal adenocarcinoma with distinct MSH6 clonal loss by immunohistochemistry in a patient who was found to have a germline pathogenic variant in MSH6.

From: Detecting mismatch repair deficiency in solid neoplasms: immunohistochemistry, microsatellite instability, or both?

Fig. 2

The MSH6 immunohistochemical stain (A) shows regions with unequivocal positive labeling and juxtaposed regions with distinct staining loss. In the regions with MSH6 loss, the staining for MSH2 (B) is reduced in intensity. The reduced MSH2 staining intensity does not appear to be related to secondary loss of MSH3 as the MSH3 staining (C) is diffuse and strong. The staining for MLH1 (not shown) and PMS2 (D) is retained throughout the tumor.

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