Fig. 2: Evaluation of tumor purity across the methylation classes.

All samples were classified by the MNP methylation-based brain classifier (version 12.5)³⁵ and (A) shows the distribution of tumor biopsies by the methylation class families and class calibrated scores. B Tumor purity estimations among methylation classes as estimated by histology, InfiniumPurify^25,26, PAMES²⁷, RF_absolute, and RF_estimate²⁸. Histopathology resulted in a more profound discrimination between the tumor methylation classes and control tissue class.