Fig. 3: Mutational spectrum in PMME and other types of melanomas. | Modern Pathology

Fig. 3: Mutational spectrum in PMME and other types of melanomas.

From: Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas

Fig. 3

A Proportion of each mutation substitution and the fraction of transition (Ti) and transversion (Tv) categories in PMME. B Proportion of each identified mutational signature in four melanoma cohorts (PMME, SKCM, MM, and UVM). C–E Proportion of mutational signatures (C) mutation substitutions (D) and synonymous and nonsynonymous SNVs in each lesion. The samples are arranged in descending order of the SBS38 contribution. F Box plot of SNVs in melanoma samples that have evidence of SBS38 or have no evidence of this signature (Mann–Whitney U test). In each box plot, the box boundaries show the first to third quartiles, and the median is the centerline. From left to right, the cohorts are PMME, SKCM, and MM, respectively.

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