Fig. 4: Comparative mutational landscape of primary melanomas from PMME, SKCM, and MM patients. | Modern Pathology

Fig. 4: Comparative mutational landscape of primary melanomas from PMME, SKCM, and MM patients.

From: Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas

Fig. 4

A Heatmap showing the frequency of the most frequently mutated genes in the five cohorts, PMME (18 cases), SKCM (398 cases), UVM (79 cases), NEMM (67 cases), and MM (including 67 NEMMs and 18 PMMEs). B Comparison of the frequency of recurrently mutated driver genes of PMME between PMME and NEMM. C Comparison of the frequency of recurrently mutated driver genes of PMME between PMME and SKCM. D Comparison of the frequency of the top 20 mutated driver genes of SKCM between PMME and SKCM. E, F Box plot with mutation burden in the UVM, SKCM, and PMME cohorts. P values determined by a two-tailed Mann–Whitney U test, *P < 0.0001.

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