Fig. 3: Examples of PD-L1 staining in tissue samples from patients with SCCHN. | Modern Pathology

Fig. 3: Examples of PD-L1 staining in tissue samples from patients with SCCHN.

From: Association of artificial intelligence-powered and manual quantification of programmed death-ligand 1 (PD-L1) expression with outcomes in patients treated with nivolumab ± ipilimumab

Fig. 3

A Illustrates low PD-L1 membrane staining in basaloid SCCHN (oval outline) with preparation artifact as outlined by the square (decreased sharpness of nuclei borders and reduced clarity of inner chromatin structure; 3,3′-Diaminobenzidine reactivity [purple staining] is blurred and indistinct from artifacts), shown at 19× magnification. B Illustrates cytoplasmic positivity (blush) (oval outline in left-hand image) at 14× magnification coincident with weak (1+) membrane PD-L1–positive staining (oval outline in right-hand image) at 30× magnification. PD-L1 programmed death ligand 1.

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