Fig. 4: Comparison of artifical intelligence–powered and manual scoring as a predictor of ORR across trials.

A Artificial intelligence-powered scoring. B Manual scoring. Associations of each trial population at the 1% and 5% cutoffs to ORR were plotted in the gray solid lines. Dotted line is the null reference representing a classifier predicting association of PD-L1 expression with random chance. Fitted sROC and 95% confidence intervals are drawn in blue. For CheckMate 026, only patients with a PD-L1 expression level ≥1% underwent randomization and were stratified according to a PD-L1 expression level of < or ≥5%. No response data are available for the adjuvant CheckMate 238 study, which was therefore excluded from this analysis. AUC area under curve, ORR objective response rate, PD-L1 programmed death ligand 1, sROC summary receiver operating characteristic.