Fig. 2: Summary of most important molecular findings including gene mutations/sequence variations, gene locus deletions and fusion gene transcripts (all genetic changes identified in this study are listed in Supplemental Database). | Modern Pathology

Fig. 2: Summary of most important molecular findings including gene mutations/sequence variations, gene locus deletions and fusion gene transcripts (all genetic changes identified in this study are listed in Supplemental Database).

From: Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature

Fig. 2

Clinical data abbreviations: F female, M male, N nasal cavity, NS nasal cavity with sinus involvement, S sinus, NP nasopharynx, P primary, R recurrence. Results of molecular and FISH studies are marked by colors. Green indicates mutations/sequence variations detected by NGS: cancer hot spot panel (CH)-grass green, comprehensive cancer panel (CC)-spruce green and SPRED1 panel-pastel green, empty box-missense mutation, d -in frame deletion, f*-STOP codon/frameshift mutation, n-NRAS mutation, k-KRAS, l-low allele frequency. Blue box indicates NF1/TP53 FISH data. Yellow indicates changes detected by ArcherDx: cis-cis fusion, i-oncogenic isoform, t-TERT fusion, nf-likely not in frame). Brown box indicates TERT Sanger sequencing data (u- unsuccessful PCR amplification but preserved DNA template). Black box indicates alterations detected by FISH and NGS. Other: 2 = two mutations, nd not done.

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