Fig. 3: Examples of oncogene and tumor suppressor gene immunohistochemistry in SNTMM. | Modern Pathology

Fig. 3: Examples of oncogene and tumor suppressor gene immunohistochemistry in SNTMM.

From: Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature

Fig. 3

A Membrane and dot-like cytoplasmic KIT(CD117) expression in p.K642E mutant. B Beta-catenin nuclear accumulation in tumors harboring CTNNB1 p.S45del. C Nuclear accumulation of TP53, mirrored by elevated nuclear expression of MDM2 (D) in NRAS p.G12D mutant.

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