Table 1 Clinical and genomic characteristics of ACCs with IGF1R hotspot non-frameshift insertions.
Tissue of origin | Sex | Age | Clinical stage | IGF1R non-frameshift insertion | IGF1R functional domain | VAF | Tumor purity |
|---|---|---|---|---|---|---|---|
Salivary gland | F | 60 | IV | R659_C663dup | Fibronectin 3 hinge | 36.0% | 40.0% |
Salivary gland | F | 70 | IV | Y662_S664dup | Fibronectin 3 hinge | 33.5% | 58.3% |
Head and neck | M | 44 | IV | Q653_K665dup | Fibronectin 3 hinge | 17.5% | 28.3% |
Salivary gland | F | 66 | N/A | T1034_V1035insN | Kinase | 39.0% | 68.5% |
Head and neck | M | 50 | N/A | A1039dup | Kinase | 45.0% | 50.0% |
Head and neck | M | 51 | N/A | M1041_R1042insL | Kinase | 12.3% | 31.5% |
Lung | F | 26 | IV | M1041_R1042insL | Kinase | 38.8% | 70.1% |
Breast | F | 68 | IV | M1041_R1042insL | Kinase | 25.6% | 31.8% |
Head and neck | F | 59 | IV | R1044_I1045insM | Kinase | 7.1% | 30.1% |
Salivary gland | F | 61 | IV | L1048dup | Kinase | 48.0% | 69.5% |
Head and neck | M | 62 | N/A | L1048dup | Kinase | 31.8% | 61.1% |
Salivary gland | M | 63 | IV | L1048dup | Kinase | 19.3% | 18.1% |
Salivary gland | F | 51 | N/A | L1048dup | Kinase | 31.3% | 59.7% |
Head and neck | F | 61 | IV | L1048dup | Kinase | 34.9% | 50.7% |
