Fig. 1: Congenital pulmonary airway malformations with mucinous cell clusters (MCCs) contain KRAS codon 12 mutations within MCCs and throughout the lesion. | Modern Pathology

Fig. 1: Congenital pulmonary airway malformations with mucinous cell clusters (MCCs) contain KRAS codon 12 mutations within MCCs and throughout the lesion.

From: Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features

Fig. 1

MCCs from separate blocks (A), lesional tissue without MCCs (B), and normal lung tissue (B) were macrodissected from 20 µm thick FFPE tissue sections. C Within each patient, the same KRAS codon 12 mutation was found throughout the lesion, including in each MCC. Adjacent uninvolved lung always had wild type KRAS sequence. *p < 0.05, binomial distribution.

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