Fig. 2: Representative photomicrographs of three cases.
From: PD-L1 and PD-1 expression in pediatric central nervous system germ cell tumors
A A germinoma with PD-L1 positive in scattered tumor cells and background macrophages, and PD-1 is positive in a subset of lymphocytes but no tumor cells. A typical prominent inflammatory infiltrate is composed of a mixture of CD4- and CD8-positive T cells and fewer CD20-positive B cells. B A choriocarcinoma with prominent PD-L1 staining and scattered PD-1-positive lymphocytes. C A MMGCT with choriocarcinoma components showing positive PD-L1 staining and scattered PD-1-positive lymphocytes. Inflammatory cells were less prominent in NGGCT than in germinomas.
