Table 3 Structural alterations of pancreatic ITPN and associated invasive carcinoma.

From: Integrative characterization of intraductal tubulopapillary neoplasm (ITPN) of the pancreas and associated invasive adenocarcinoma

ID case

Histology

Involved genes

Type of alteration

Gene 1 (region)

Gene 2 (region)

1

Tubular

FGFR2 (exon 17)

HSD17B4 (exon 13)

Fusion

Papillary

FGFR2 (exon 17)

HSD17B4 (exon 13)

Fusion

3

Tubular

RET (exon 12)

C14orf93 (exon 3)

Fusion

Papillary

–

–

–

4

Tubular

TRIM24 (exon 9)

RET (exon 12)

Fusion

Papillary

TRIM24 (exon 9)

RET (exon 12)

Fusion

5

Tubular

LMNA

RB1

Translocationa

Papillary

LMNA

RB1

Translocationa

8

Tubular

FGFR2 (exon 17)

SYCP1 (exon 24)

Fusion

AC

FGFR2 (exon 17)

SYCP1 (exon 24)

Fusion

11

Tubular

–

–

–

Papillary

–

–

–

AC

ERBB2 (exon 24)

P3H4 (exon 2)

Fusion

  1. ITPN intraductal tubulopapillary neoplasm.
  2. aThis is a translocation by asymmetric breakdown and repair of chromosomes 1 (1q22, LMNA gene) and 13 (13q14.2, RB1 gene), resulting in a dicentric and an acentric chromosome that contains the distal parts of the q arms, welded together. In particular, regarding LMNA and RB1, there is the 3’-3 ‘and 5’-5’ junction of the truncates, resulting in the loss of genes.
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