Table 2 Multivariable Cox proportional hazards model for overall survival (OS).

From: Expression of phosphorylated ribosomal protein S6 in mesothelioma patients - correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project

No. of patients = 362* No. of deaths = 313

Hazard Ratio

95% CI

p-value

Interaction effects

pS6 status*Histology

  

<0.001

 High vs. Low

  In Epithelioid

0.87

(0.66–1.14)

0.31

  In Non-epithelioid

2.12

(1.42–3.17)

<0.001

 Epithelioid vs. Non-epithelioid

  In High pS6

0.26

(0.18–0.38)

<0.001

  In Low pS6

0.64

(0.46–0.89)

0.0075

Main effects

Gender

 Female vs. Male

0.55

(0.39–0.79)

0.0011

Treatment strategy

 Complete Resection vs. Palliative

0.50

(0.39–0.64)

<0.001

  1. (*) 2 patients who haven’t received treatment are excluded.
  2. Note1: Variables of interest initially included in the model: Gender, Ethnicity, ECOG performance status, Smoking history, Exposure to asbestos, Age at diagnosis, Histology, Localization of tumour, Clinical staging, Treatment strategy.
  3. Note2: P-values corresponding to the non-significant variables: Age at diagnosis: 0.87; Exposure to asbestos: 0.58; Clinical staging: 0.61; Ethnicity: 0.68; Smoking history: 0.54; ECOG performance status: 0.31; Localization of tumour: 0.21.
  4. Note3: Ethnicity: Categories African, East Asian and Other are combined; Smoking history: Categories Current and Former are combined; Exposure to asbestos: Categories Yes and Possible are combined.
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