Fig. 3: Extended 22q loss in SMARCB1-deficient sarcomas.
From: The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms
A Cohort-level copy number segmentation plot showing proportion of copy number alterations on chromosome 22q, highlighting the genes flanking SMARCB1 (22q11.23), from centromeric to telomeric: CRKL (22q11.21), MAPK1 (22q11.21), CHEK2 (22q12.1), NF2 (22q12.2), EP300 (22q13.2), among SMARCB1-deficient sarcomas. B Oncoprint showing SMARCB1-deficient sarcomas and corresponding tumor types with or without copy number alterations at the flanking genes, CRKL, MAPK1, CHEK2, NF2, and EP300.
