Table 2 Clinicopathologic characteristics of DHL/THL in GI.

From: Double/triple hit lymphoma in the gastrointestinal tract: clinicopathological features, PD-L1 expression and screening strategy

Case #

Sex

Age (y)

Location

History (mo)

Timing of diagnosis

B symptoms

CNS involvement

Stage

Regimen for the first-line treatment

Survival after diagnosis (mo)

Current status

EBER

HBV infection status

Morphology

DHL/THL

1

F

70

Stomach

NA

Transformationa

No

No

III

R-CHOP

43

AWD

NHHI

D

D1

2

M

23

Colon

2

De novo

Yes

No

IVA

CHOP

37

AWD

NHHI

D

D2

3

F

56

Stomach

1

De novo

NA

No

IV

R-CHOP

1

DOD

NA

NA

D

D1

4

F

49

Rectum

1

De novo

No

No

IV

R-CHOP

6

DOD

PHI

D

D1

5

M

42

Small intestine

3

De novo

Yes

No

II

R-CHOP+HD-MTX+IT

25

AWD

NHHI

D

D2

6

M

57

Stomach

3

NA

NA

NA

NA

NA

2

DOD

+

NA

D

D2

7

M

81

Stomach

1

De novo

Yes

No

IV

NA

2

DOD

PHI

D

D2

8

F

59

Stomach

1

De novo

Yes

No

IIE

DA-R-EPOCH +HD-MTX+IT

9

AWD

NHHI

D

THL

9

M

82

Small intestine

5

De novo

No

NA

IV

R+lenalidomide

5

AWD

+

PHI

B

D2

10

F

52

Stomach

6

De novo

Yes

NA

IV

NA

5

DOD

NA

D

D2

11

M

47

Stomach

1

De novo

Yes

NA

IV

NA

1

DOD

PHI

B

D1

12

M

46

Colon

1

De novo

No

No

IV

R-CHOP-E

LFU

LFU

PHI

D

D1

13

M

48

Caecum

2

NA

No

No

IVA

CHOP

16

AWD

NA

D

D1

14

M

62

Jejunum

6

De novo

No

No

II

NA

18

AWD

PHI

D

D2

15

F

20

Stomach

NA

NA

NA

NA

NA

NA

LFU

LFU

NA

D

D2

  1. DHL/THL double-hit/triple-hit lymphoma, GI gastrointestinal tract, F female, M male, AWD alive with disease, DOD dead of disease, CHOP the regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone, DA-R-EPOCH dose-adjusted regimen of rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin, HD-MTX high-dose methotrexate, IT intrathecal injection, LFU lost to follow-up, LN lymph node, NA not applicable, R-CHOP the regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, R-CHOP-E the regimen of R-CHOP with the addition of etoposide, PHI previous HBV infection, NHHI no history of HBV infection, Morphology B BCLU, Morphology D DLBCL, D1 MYC/BCL2, D2 MYC/BCL6.
  2. aTransformation: this case was transformed from DLBCL.