Fig. 1: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm. | Modern Pathology

Fig. 1: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm.

From: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: first two cases with clinicopathologic and molecular comparison to eight visceral counterparts

Fig. 1

Case 1 A, B shows a poorly differentiated malignant neoplasm with sheet-like growth occupying the dermis after component:...without an in-situ component (A). Higher magnification shows that the tumor is composed of pleomorphic epithelioid cells with amphophilic cytoplasm and variably prominent nucleoli. Mitoses are easily identified, and apoptotic cells are present (B). Case 2 C, D shows a remarkably similar morphology. A low power image shows a dermally-based tumor lacking an in-situ component with a more nested architecture (C). Higher magnification shows that the tumor is composed of pleomorphic epithelioid cells with variably prominent nucleoli and focal rhabdoid morphology (arrow, D). Mitoses are frequent. (All images show H&E-stained slides. Panels A and C, 100 x magnification. Panels B and D, 400 x magnification).

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