Fig. 2: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm immunohistochemical profile. | Modern Pathology

Fig. 2: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm immunohistochemical profile.

From: Primary cutaneous SMARCA4-deficient undifferentiated malignant neoplasm: first two cases with clinicopathologic and molecular comparison to eight visceral counterparts

Fig. 2

Case 1 is depicted in the top row A–C, and case 2 is depicted in the bottom row D–F. Both cases showed complete loss of staining of SMARCA4 (A, D; note retained nuclear expression in non-neoplastic cells). Primary cutaneous SMARCA4-deficient malignant neoplasms also express pan-keratin (B, E) and Sox-2 (C, F). E shows small volume of tumor due to loss of tissue on deeper levels. All images depict 200x magnification.

Back to article page