Table 2 Tumor morphology in association with the relationship of tumor cells to the free peritoneal surface in micrometers (µm).
Total (n = 189) | Full peritoneal penetration (n = 89) | 0–99 µm to peritoneum (n = 34) | 100–999 µm to peritoneum (n = 33) | ≥1000 µm to peritoneum (n = 33) | p value | |
|---|---|---|---|---|---|---|
Histopathological characteristics | ||||||
Type and differentiation | ||||||
Well/moderately differentiated adenocarcinoma | 135 (71) | 60 (67) | 23 (68) | 23 (70) | 29 (88) | 0.017 |
Poorly differentiated adenocarcinoma | 23 (12) | 9 (10) | 8 (24) | 6 (18) | 0 (0) | |
Mucinous carcinoma | 20 (11) | 10 (11) | 3 (9) | 3 (9) | 4 (12) | |
Signet ring cell carcinoma | 11 (6) | 10 (11) | 0 (0) | 1 (3) | 0 (0) | |
Tumor border configuration | ||||||
Pushing | 55 (29) | 9 (10) | 8 (24) | 21 (64) | 17 (52) | <0.001 |
Infiltrating | 134 (71) | 80 (90) | 26 (76) | 12 (36) | 16 (48) | |
Tumor budding | ||||||
Low budding (Bd1) | 66 (35) | 22 (25) | 13 (38) | 14 (42) | 17 (52) | 0.012 |
Intermediate budding (Bd2) | 28 (15) | 10 (11) | 5 (15) | 6 (18) | 7 (21) | |
High budding (Bd3) | 95 (50) | 57 (64) | 16 (47) | 13 (39) | 9 (27) | |
Tumor-stroma ratio | ||||||
Stroma-low (≤50% stroma) | 84 (44) | 29 (33) | 17 (50) | 21 (64) | 17 (52) | 0.011 |
Stroma-high (>50% stroma) | 105 (56) | 60 (67) | 17 (50) | 12 (36) | 16 (48) | |
Venous invasion | 100 (53) | 55 (62) | 18 (53) | 15 (45) | 12 (36) | 0.066 |
Lymphatic invasion | 78 (41) | 44 (49) | 15 (44) | 12 (36) | 7 (21) | 0.036 |
Perineural invasion | 103 (54) | 57 (64) | 23 (68) | 14 (42) | 9 (27) | <0.001 |
Lymph node status | ||||||
pN0 | 50 (26) | 19 (21) | 5 (15) | 9 (27) | 17 (52) | 0.018 |
pN1 (1–3 positive nodes) | 67 (35) | 30 (34) | 14 (41) | 14 (42) | 9 (27) | |
pN2 (4+ positive nodes) | 72 (38) | 40 (45) | 15 (44) | 10 (30) | 7 (21) | |
Tumor deposits | 54 (29) | 30 (34) | 9 (26) | 10 (30) | 5 (15) | 0.242 |
Peritoneal changes according to Panarelli et al. | 165 (87) | 88 (99) | 33 (97) | 29 (88) | 15 (45) | 0.001 |
Irradical resection (R1) | 25 (13) | 6 (7) | 4 (12) | 10 (30) | 5 (15) | 0.010 |
pT4b | 35 (19) | 2 (2) | 5 (15) | 17 (52) | 11 (33) | <0.001 |
Tissue sampling for histological assessment | ||||||
No. of tissue blocks, mean (SD) | 5.28 (2.84) | 4.61 (1.55) | 5.38 (2.84) | 6.21 (4.59) | 6.06 (2.92) | 0.055 |
No. of tissue blocks relevant to pT4a assessment, mean (SD) | 3.56 (2.54) | 3.29 (1.61) | 3.21 (2.51) | 4.36 (3.87) | 3.82 (2.87) | 0.086 |
