Fig. 1: Representative pictures from the S3 subcluster in a case of invasive mucinous adenocarcinoma. | Modern Pathology

Fig. 1: Representative pictures from the S3 subcluster in a case of invasive mucinous adenocarcinoma.

From: MUC6 distribution in the spectrum of pulmonary mucinous adenocarcinoma

Fig. 1

This pulmonary invasive mucinous adenocarcinoma shows a labyrinthine pattern of growth with lepidic growth (A) and is hallmarked by mucin-laden columnar cells with basal nuclei, absence of mitoses or apoptotic bodies and uniform histologic appearance with tufting (A, inset). Tumor cells are diffusely positive for MUC1 on cell membrane (B), and show cytoplasmic decoration for MUC6 along with CDX2 negativity (C, inset). Nuclear decoration for HNF4-alpha is accompanied by complete lack of TTF1 labeling (D, inset).

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