Fig. 2
Enrichment of the filtered regulatory variants and the protein-coding variants from ASD cases in different ASD-associated datasets AXAS-ASD (n = 2664) [30], SFARI (n = 397) [47], M13 - Li 2014 (n = 115) [48], and GWAS-ASD (ASD associated genes as described in the NHGRI-EBI GWAS Catalog). Two unrelated disease control datasets, coronary artery disease (GWAS-CAD), and Crohn’s disease (GWAS-Crohn) were also retrieved from the NHGRI-EBI GWAS Catalog. The bar graph shows –log10(P-values) for the Z-scores (Supplementary Table 3). Only genes found in the Human Genome Nomenclature Consortium (HGNC) database and the whole protein-protein interaction network [30] were considered as the background datasets used for Z-score calculations (Supplementary Table 3)
