Fig. 2
From: Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
Antibiotic treatment reverses HFD-induced depressive and anxiety-like behaviors. a Time spent in light compartment during light/dark box test of mice on a Chow or HFD with or without Abx treatment (n = 18/group). b Assessment of conflict-based anxiety as latency to feed and time spent in the center zone during novelty suppressed feeding test (n = 18/group). c Number of entries and time spent in the center during open-field exploration (n = 18/group). d Assessment of anxiety as number of buried marbles during a marble-burying task (n = 14/group). e Assessment of anxiety as number of buried marbles during a marble-burying task of chow or HFD recipient GF-mice 2 weeks after bacterial transfer from mice treated with chow/HFD with or without Abx (n = 6/group). C chow, H HFD, M HFD + metronidazole, V HFD + vancomycin. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 by ANOVA, followed by pre-planned t-tests
