Table 3 Association analysis of affective disorder and multiple related traits across the linkage regions in GS and UKB

GS_GWAS

3.39 CAPN8

3.84 GRM5

3.28 CNTN5

3.67 PDE4D

3.63 LRRC7

3.0 VSNL1

4.18 BCHE

3.32 GLRB

4.59 PRKCB

UKB_GWAS

3.18 TLR5

2.78 GRM5

3.82 CNTN5

3.92 PDE4D

3.68 LRRC7

4.05 VSNL1

4.16 EGFEM1P

5.2

5.09 TNRC6A

Neuroticism

2.05

1.96

3.08

2.91

2.17

2.06

3.10

2.77

3.21

Extroversion

2.45

2.60

2.29

5.22 PPWD1

2.73

2.07

2.33

2.22

2.77

Digit symbol coding

2.94

2.21

3.41 CNTN5

2.57

2.35

2.79

2.32

3.56 RAPGEF2

3.12

Verbal fluency

2.94

2.24

2.64

3.10

2.22

3.04

2.40

2.94

2.75

Vocabulary

3.01

2.43

3.49 CNTN5

4.54 PDE4D

2.83

2.49

2.79

3.55 RAPGEF2

2.59

Logical memory

2.22

2.17

2.49

4.22 RAB3C

1.92

2.48

2.24

3.34 LINC02233

3.84 SCNN1B

g Factor

1.90

2.25

3.33 CNTN5

3.31 MAST4

2.31

3.02

1.83

3.58 RAPGEF2

2.81

GHQ total

2.34

4.03 5’ RAB38

3.76 CNTN5

3.73 RNF180

2.15

3.12

1.80

2.84

3.26

MDD

2.22

3.04

2.03

3.74 PDE4D

2.83

2.35

2.79

3.27

3.93 HS3ST4

MDQ total

2.88

1.26

3.16

3.29

2.52

3.80 3’KCNS3

2.63

2.62

2.93

SPQ total

2.42

3.13

2.17

3.91 MAST4

3.04

1.39

2.74

2.91

2.87

Age of onset

3.25

2.44

3.32 CNTN5

3.28

2.27

2.05

2.64

2.33

2.68

Episode count

2.84

2.17

3.55 CNTN5

2.53

3.24

1.99

2.52

1.90

3.54 HS3ST4

Region (Mb)

223–225

87.5–89

98.5–100.5

58–67

69–71

17.5–18.5

168–172

158–162

21–27

Genotyped SNPs

382

363

585

1511

297

214

698

563

1239