Fig. 3
From: Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders
Complexity and variability of the PFC lipidome. a Left panel: number of lipids detected in each sample across the lifespan, with four stages indicated by colors and silhouette symbols. Lines represent spline curves built with three degrees of freedom. Right panel: standard deviation distributions of log10-transformed concentrations of 5024 lipids within a sliding window (window size = 10 samples, step size = 5 samples). Boxes show the first and third quartiles of the distribution. Error bars show the maximum and minimum standard deviation values. b Number of detected lipids and standard deviations of the lipid concentrations at the adult stage (window size = 6 samples, step size = 3 samples). c Median magnitude of concentration differences of 5024 detected lipids within 18 age intervals evenly spaced across the lifespan (red bars, top) and 14 intervals evenly spaced across the adult stage (red bars, bottom). The magnitude of concentration differences for each lipid was calculated as the ratio of lipid concentration difference within an age interval and the median lipid concentration across intervals. The gray bars show the median magnitude of lipidome differences expected by chance based on permutations of the age labels 1000 times. The x-axis labels show the median age of each interval
