Fig. 6

Correlation between disorder-associated (DA) and temporal changes in the human PFC lipidome. a Schematic representation of DA and temporal lipidome changes observed in our study. b The relationship of DA and temporal lipidome differences among lifespan stages. For each disorder, the left five columns show the relative concentrations of the corresponding DA lipids across lifespan stages (red—higher concentration compared to the lifespan median, blue—lower concentration). The right column shows concentration difference of the corresponding DA lipids between disorder and age-matched control samples (red—higher concentration in disease, blue—lower concentration). The darker shade indicates larger differences. The adult stage is represented by two columns corresponding to 30–65 and 65–99-year intervals. c The relationship of DA and temporal lipidome differences among 79 sliding windows covering the lifespan. Dots represent the Pearson correlation coefficient (r) values for each window. Curves represent spline curves built with three degrees of freedom. The two windows with the highest PCC values are highlighted in dark red, with red vertical dash lines showing their median age. Yellow shaded areas show patients’ age ranges, with gray vertical dash lines showing the median age. Horizontal gray dash lines and gray shaded areas indicate r = 0 and the corresponding 99.8% confidence interval estimated using Rahman r distribution [84]