Fig. 7
From: Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders
Predicted membrane fluidity levels at lifespan stages and in disorders. a Relative membrane fluidity estimates at lifespan stages predicted using the following features (from top to bottom): (i) total cholesterol concentration, (ii) ratio of cholesterol to phospholipid concentration, proportion of saturated (iii) phospholipids, (iv) PC, (v) PE and relative unsaturation degree of fatty acyl of (vi) GP, (vii) PC, and (viii) PE, respectively. Each cell shows relative levels of the features across lifespan stages, with each column representing one stage. The adult stage is shown by two columns representing 30–65-year and 65–99-year intervals. Inverted relative levels are shown for features i–v, which negatively correlate with membrane fluidity. b Relative membrane fluidity estimates in three disorders. The features are the same as in panel a. Each cell shows log2-transformed fold change in disorder compared to age-matched controls. Gray cells represent the absence of significant changes (Wilcoxon rank-sum test, BH-corrected P > 0.1)
