Fig. 4 | Molecular Psychiatry

Fig. 4

From: Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

Fig. 4Fig. 4

The functional analysis results for target genes. Out of 257 target genes, only genes meeting at least three functional criteria are listed. The criteria include: (1) differential expression in at least two Alzheimer disease studies that up- or downregulated consistently in different studies; (2) expression in the brain cells (Barres website); (3) having cis-eQTL effects in any brain tissues using GTEx database (P < 0.05); 4) mediating genetic effects on PiB (SMR analysis with P < 0.05) in any brain tissues; (5) having cis-eQTL effects in whole blood (P < 0.05); (6) mediating genetic effects on PiB (SMR analysis with P < 0.05) in whole blood; and (7) included in nominally significant pathways. The detailed results are summarized in Supplementary Table S6

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