Fig. 1
CircDYM was downregulated in the MDD patients and the depressive-like animal models. a circDYM contains one site that is complementary to miR-9 according to the bioinformatics program RNAhybrid. b Levels of circDYM were decreased in the peripheral blood of MDD patients (n = 50) compared with those of normal controls (n = 30). All the data were presented as mean ± SEM. **p < 0.01 versus normal control group using Student’s t test. c Correlation between circDYM expression and TEPS-A scores using the Pearson’s correlation coefficient. d Interactive effects of circDYM and CTQ scores on TEPS-A scores in MDD patients using Multivariate Linear Regression. MDD patients with lower circDYM and CTQ scores showed more severe depressive symptoms. e Expression of circDYM in the plasma of CUS mice. After exposure to CUS for 5 weeks, mice were sacrificed. Plasma was collected, and RNA was isolated for examination of circDYM by real-time PCR. All data were presented as mean ± SEM. n = 10 mice/group, **p < 0.01 versus Control using Student’s t test. f Expression of circDYM in the hippocampus of CUS mice. After exposure to CUS for 5 weeks, mice were sacrificed. The hippocampus was collected, and RNA was isolated for examination of circDYM by real-time PCR. All data were presented as mean ± SEM. n = 8 mice/group, *p < 0.05 versus Control using Student’s t test. g Expression of circDYM in the plasma of mice treated with LPS. Mice were intraperitoneally injected with LPS (1 mg/kg) or saline for 5 successive days and then sacrificed. Plasma was collected, and RNA was isolated for examination of circDYM by real-time PCR. All data were presented as mean ± SEM. n = 11-12 mice/group, **p < 0.01 vs. Control using Student’s t test. h Expression of circDYM in the hippocampus of mice treated with LPS. Mice were intraperitoneally injected with LPS (1 mg/kg) or saline for 5 successive days and then sacrificed. The hippocampus was collected, and RNA was isolated for examination of circDYM by real-time PCR. All the data were presented as mean ± SEM. n = 7 mice/group, ***p < 0.001 vs. Control using Student’s t test
