Fig. 2
From: Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype
GWAS variant enrichment in retinoid genes and their relative tissue specificity. a Enrichment of schizophrenia GWAS variants in retinoid genes, genes highlighted blue are below the threshold of nominal uncorrected significance (P < 0.05). b Tissue-specific expression of 22 significant MAGMA genes relative to the rest of the retinoid panel. Bars highlighted red are statistically significant after multiple testing correction. One-sided (for upregulation and downregulation) and two-sided tests are reported. DEG = differentially expressed genes. c Distribution of retinoid polygenic risk score (PRSRet), constructed using the most significantly associated P-value threshold, in the schizophrenia and healthy control cohorts. The black line represents the population mean for controls (left) and cases (right)
