Fig. 3

Rare variants in the retinoid receptor gene RARB enriched in a severe cognitive subtype of schizophrenia. a The combined effect of rare variants was tested at gene level using the SKAT-O test; analyses comparing cases with controls, and directly comparing cognitively spared [CS] with cognitive deficit [CD] cases of schizophrenia were conducted. Blue Bonferroni threshold corrected for the 22 genes tested for two phenotypes. b, c Expression of RARB in different brain regions from BrainSpan at (b) 13–15 weeks post conception (pcw) and (c) 6–18 months (mos) post-natal development. STC = caudal superior temporal cortex, A1C = primary auditory cortex, IPC = inferior parietal cortex, S1C = primary somatosensory cortex, M1C = primary motor cortex, DFC = dorsolateral prefrontal cortex, VFC = ventrolateral prefrontal cortex, OFC = orbital frontal cortex, ITC  =inferior temporal cortex, V1C = primary visual cortex, STR = striatum, MFC = medial prefrontal cortex, OFC = orbital frontal cortex, AMY = amygdala, HIP = hippocampus, CB = cerebellum