Fig. 4

Association between RARB rare variant burden and neurophysiological phenotypes. a Interaction between RARB rare variant burden and volume (right) of a voxel cluster in the exterior of the left posterior cerebellum (left). Red points indicate the cognitive deficit (CD) subtype, whereas blue points represent cognitively spared (CS) schizophrenia cases. Coordinates of the significant cluster with reduced volume after voxel-wise correction (x, y and z) are stated. b Inter-subject covariance of grey matter significantly predicted by RARB rare variant burden in CD patients in regions outside the cerebellum. Source-based morphometry identified components (spatial regions) in which the covariation of grey matter concentration (GMC) was interrelated between individuals. Z-value indicates correlation between subjects, with a positive Z-value representing positively correlated inter-subject covariation and vice versa. Component C23: orange positive z-value region – precuneus, postcentral gyrus, paracentral lobule, sub-gyral, superior parietal lobule, inferior parietal lobule, medial frontal gyrus; blue negative z-value region – middle temporal ggyrus, inferior occipital gyrus. Component C8: orange positive z-value region – precuneus, sub-gyral, cuneus, superior parietal lobule; blue negative z-value region – middle temporal gyrus, angular gyrus, superior temporal gyrus