Table 2 Differential protein expression in PE

From: Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

 

PE study findings

Protein names

Gene names

Fold change

p-value

FDR

Vitronectin

VTN

1.219

0.00150

0.02226

Complement C1r subcomponent-like protein

C1RL

1.291

0.00154

0.02226

Complement component C8 beta chain

C8B

1.270

0.00352

0.03399

Complement component C8 alpha chain

C8A

1.207

0.00535

0.03537

Complement factor H

CFH

1.207

0.00610

0.03537

Complement C5

C5

1.161

0.00847

0.04096

C4b-binding protein alpha chain

C4BPA

−1.155

0.02734

0.11326

Complement C2

C2

1.124

0.03709

0.13446

Mannan-binding lectin serine protease 1

MASP1

1.193

0.05725

0.18448

Complement C1s subcomponent

C1S

1.118

0.07756

0.22036

Complement factor B

CFB

1.103

0.08624

0.22036

Complement component C8 gamma chain

C8G

1.162

0.09791

0.22036

Complement C1q subcomponent subunit A

C1QA

1.139

0.09878

0.22036

Complement C4-A

C4A

1.122

0.11874

0.24596

Complement C1q subcomponent subunit B

C1QB

1.251

0.15870

0.30683

Complement factor I

CFI

1.094

0.20871

0.36678

Clusterin

CLU

1.097

0.21501

0.36678

Complement C1r subcomponent

C1R

1.095

0.23435

0.37756

Complement component C6

C6

1.078

0.28313

0.43214

Complement C1q subcomponent subunit C

C1QC

1.068

0.32245

0.46611

C4b-binding protein beta chain

C4BPB

−1.087

0.33762

0.46611

Complement factor H-related protein 5

CFHR5

−1.189

0.35984

0.46611

Complement component C9

C9

1.066

0.36968

0.46611

Complement factor D

CFD

1.235

0.38710

0.46774

Plasma protease C1 inhibitor

SERPING1

1.106

0.41419

0.48046

Mannose-binding protein C

MBL2

1.069

0.61155

0.68211

Complement C4-B

C4B

1.077

0.73548

0.78996

Complement component C7

C7

1.023

0.78675

0.81485

Complement C3

C3

−1.018

0.84266

0.84266

  1. Semi-targeted proteomic analysis of 29 biomarker candidates between cases (n = 64) and controls (n = 67) in the PE cohort. Protein level data were assessed for significance between the PE cases and healthy controls, following correction for False Discovery as described by Benjamini-Hochberg [52], and following adjustment for BMI and gender, respectively. The protein name, gene name, fold change (FC) in disorder, ANCOVA adjusted p-values, and FDR cutoff values are listed for all 29 proteins profiled. Proteins are sorted by p-value for the PE study. The FDR positive findings are depicted in bold
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